Aldo-keto reductase 1B: Much learned, much more to do

Abstract excerpt

The Aldo-Keto Reductase 1B (AKR1B) subfamily was initially known for its association with the pathogenesis of secondary diabetic complications such as retinopathy, neuropathy, nephropathy, and cataracts. Unfortunately, over the past few decades, all drug development efforts targeting this family have failed for one reason or another. Recently, a growing body of evidence showing the deep involvement of AKR1B in met...

Topics

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• Aldose Reductase and Taurine
• Heme Oxygenase-1 and Carbon Monoxide
• Prenatal Substance Exposure Effects

Identifiers and source

Literature Corpus work

f4aeaddd-4772-5e14-b47f-e9e1ba3cb384

DOI

10.1016/j.hlife.2023.12.002