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Article

Inherent sex‐dependent regulation of human hepatic CYP3A5

19 Sept 2012

Abstract excerpt

BACKGROUND AND PURPOSE: Expression of hepatic cytochromes P450 (CYP) in all species examined, including humans, is generally sexually dimorphic. We examined the sex-dependent expression of CYP3A5 and the hormone-regulated molecular mechanism(s) responsible for any dimorphism. EXPERIMENTAL APPROACH: CYP3A5 levels as well as nuclear translocation and promoter binding of transcription factors regulating CYP3A5...

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PMID: 22994453
DOI: 10.1111/j.1476-5381.2012.02222.x

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