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Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes

20 Aug 2018

Abstract excerpt

Aldo-keto reductases (AKRs) are monomeric NAD(P)(H)-dependent oxidoreductases that play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C enzymes acting as 3-ketosteroid, 17-ketosteroid, and 20-ketosteroid reductases are involved in the prereceptor regulation of ligands for the androgen, estrogen, and progesterone receptors and are considered drug targets to treat steroid...

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PMID: 30137266
DOI: 10.1210/er.2018-00089

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