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Article

Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Dec 2008

Thorpe Julian R, Tang Helen, Atherton Joe, Cairns Nigel J

Abstract excerpt

TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of the pathological inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy, also called FTLD with ubiquitin-positive, tau-negative inclusions (FTLD-U), and motor neuron disease (MND). TDP-43 is predominantly expressed in the nucleus and regulates gene expression and splicing. In FTLD with TDP-43 proteinopathy, neuronal inclusions...

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PMID: 18974920
DOI: 10.1007/s00702-008-0137-1
PMCID: PMC2789307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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