Article

Modulation of retroviral capsid assembly halts ARC-mediated TDP-43 intercellular spreading

2026-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Intercellular propagation of pathological TDP-43 drives the progression of ALS and FTD, yet the mechanisms enabling transmission remain elusive. Here, we demonstrate that Activity-regulated cytoskeleton associated protein (ARC/Arg3.1) is pathologically subverted to act as a retroviral-like capsid vehicle for TDP-43 spreading. In a Drosophila model, we reveal that massive Arc1 upregulation drives...

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Literature Corpus work: 9e9ad658-7441-5e06-a834-d314a4411905
DOI: 10.64898/2026.07.13.738236

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