Article

APOE4 affects basal and NMDAR mediated protein synthesis in neurons by perturbing calcium homeostasis

2020-12-11

Abstract excerpt

Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in humans – APOE2, APOE3, and APOE4. APOE4 is the most well-established risk factor increasing the pre-disposition for Alzheimer’s disease. The presence of the APOE4 allele alone is shown to cause synaptic defects in neurons and recent studies have identified multiple pathways directly influenced by APOE4. However, the mechani...

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Literature Corpus work: 74c1ffaf-64f6-5bad-99ef-27060dc4f347
DOI: 10.1101/2020.12.10.418772

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