Article

Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loading

2023-06-28

Abstract excerpt

<title>Abstract</title><p><bold>Background</bold>ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling. In the adult brain, Reelin potentiates excitatory synapses and thereby protects against amyloid-β toxicity. Recently, a gain-of-function mutation in Reelin that...

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Literature Corpus work: 76da2350-a9fe-5713-9040-b9cf62cd53b1
DOI: 10.21203/rs.3.rs-3040567/v1

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