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Article

ApoE isoform-dependent changes in hippocampal synaptic function

27 May 2009

Abstract excerpt

The lipoprotein receptor system in the hippocampus is intimately involved in the modulation of synaptic transmission and plasticity. The association of specific apoE isoform expression with human neurodegenerative disorders has focused attention on the role of these apoE isoforms in lipoprotein receptor-dependent synaptic modulation. In the present study, we used the apoE2, apoE3 and apoE4 targeted replacement...

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PMID: 19725929
DOI: 10.1186/1750-1326-4-21

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