Article
Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.
Neurobiology of disease - 1 Feb 2006
Xu Pu-Ting, Li Yi-Ju, Qin Xue-Jun, Scherzer Clemens R, Xu Hong, Schmechel Donald E, Hulette Christine M, Ervin John, Gullans Steven R, Haines Jonathan, Pericak-Vance Margaret A, Gilbert John R
Abstract excerpt
Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). The mechanism of action of APOE in the etiology of AD remains unclear. Using gene expression (microarray) analysis of human hippocampus from APOE3/3 AD and APOE4/4 AD cases, we found different gene transcription patterns between APOE4/4 and APOE3/3 AD cases. The expression of APOE4/4 alleles, in...
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