Article

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

2024-01-12

Abstract excerpt

<h4>ABSTRACT</h4> In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause Long QT Syndrome (LQTS), a syndrome with a prolonged QT interval on the ECG, which increases the risk of ventricular arrhythmia and sudden cardiac death. One potential therapeutical intervention f...

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Literature Corpus work: 74957da3-f4be-5ff4-8ddd-821cb29e3776
DOI: 10.1101/2024.01.11.575247

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