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Article

An electrostatic potassium channel opener targeting the final voltage sensor transition.

The Journal of general physiology - 1 Jun 2011

Börjesson Sara I, Elinder Fredrik

Abstract excerpt

Free polyunsaturated fatty acids (PUFAs) modulate the voltage dependence of voltage-gated ion channels. As an important consequence thereof, PUFAs can suppress epileptic seizures and cardiac arrhythmia. However, molecular details for the interaction between PUFA and ion channels are not well understood. In this study, we have localized the site of action for PUFAs on the voltage-gated Shaker K channel by...

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Share to Fatty Acids, Unsaturated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Voltage-Gated

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Source

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Identifiers

PMID: 21624947
DOI: 10.1085/jgp.201110599
PMCID: PMC3105513

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