Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2.

doi:10.1093/europace/euaf168

Article

Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Sept 2025

Louradour Julien, Hornyik Tibor, De la Cruz Alicia, Hiniesto-Iñigo Irene, Alerni Nicolò, Barbieri Miriam, Lopez Ruben, Perez-Feliz Stefanie, Matas Lluís, Nimani Saranda, Giammarino Lucilla, Koren Gideon, Zehender Manfred, Brunner Michael, Liin Sara I, Larsson H Peter, Odening Katja E

Abstract excerpt

AIMS: Loss-of-function mutations in KCNQ1 and KCNH2 (α-subunits of the slow delayed IKs and rapid delayed IKr-conducting repolarising K+ channels) lead to long QT syndrome type 1 (LQT1) and 2 (LQT2), respectively. These channelopathies present with longer action potential duration (APD) and prolonged QT interval on electrocardiogram, which can ultimately lead to deadly arrhythmias. Here, we investigated the...

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Topics

Animals
Long QT Syndrome
Action Potentials

Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2.

Abstract excerpt

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