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Article

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Liin Sara I, Silverå Ejneby Malin, Barro-Soria Rene, Skarsfeldt Mark Alexander, Larsson Johan E, Starck Härlin Frida, Parkkari Teija, Bentzen Bo Hjorth, Schmitt Nicole, Larsson H Peter, Elinder Fredrik

Abstract excerpt

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as IKs channel modulators. We report that PUFAs open Kv7.1 via an electrostatic mechanism. Both the polyunsaturated acyl tail and the negatively charged carboxyl head group are required for PUFAs to...

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Identifiers

PMID: 25901329
DOI: 10.1073/pnas.1503488112
PMCID: PMC4426425

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