Article

TCR-FramePose: a local-frame representation for decomposing global docking and CDR3 loop geometry in TCR-pMHC recognition

2026-07-04

Abstract excerpt

T cell receptor recognition of peptide–MHC depends on sequence, interface chemistry, and three-dimensional geometry, but docking geometry is often summarized at the whole-receptor level, leaving CDR3-local pose difficult to compare across structures. We introduce TCR-FramePose, a local-frame descriptor set that represents each TCR–pMHC complex as three bodies — whole TCR, CDR3α, and CDR3β — measured relative to a...

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Identifiers and source

Literature Corpus work: 748e32fb-7f93-5441-aecb-f35b2b0d0c9e
DOI: 10.64898/2026.06.30.735664

Open publication

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