Article
A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.
Protein engineering, design & selection : PEDS - 1 Dec 2016
Riley Timothy P, Ayres Cory M, Hellman Lance M, Singh Nishant K, Cosiano Michael, Cimons Jennifer M, Anderson Michael J, Piepenbrink Kurt H, Pierce Brian G, Weng Zhiping, Baker Brian M
Abstract excerpt
T-cell receptors (TCRs) have emerged as a new class of therapeutics, most prominently for cancer where they are the key components of new cellular therapies as well as soluble biologics. Many studies have generated high affinity TCRs in order to enhance sensitivity. Recent outcomes, however, have suggested that fine manipulation of TCR binding, with an emphasis on specificity may be more valuable than large...
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