Article
An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.
Structure (London, England : 1993) - 6 Jul 2016
Harris Daniel T, Singh Nishant K, Cai Qi, Smith Sheena N, Vander Kooi Craig, Procko Erik, Kranz David M, Baker Brian M
Abstract excerpt
Utilizing a diverse binding site, T cell receptors (TCRs) specifically recognize a composite ligand comprised of a foreign peptide and a major histocompatibility complex protein (MHC). To help understand the determinants of TCR specificity, we studied a parental and engineered receptor whose peptide specificity had been switched via molecular evolution. Altered specificity was associated with a significant change...
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