Article

Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients

2017-01-01

Abstract excerpt

When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable prognostic factor. A total of 85 consecutive samples of newly diagnosed untreated patients with AL were included in the study after they provided their informed consent. FLT3...

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Literature Corpus work: 74842c0b-76db-54f2-948a-b113c301287f
DOI: 10.1590/s2175-97902017000216105

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