Article
Distinct FLT3 Pathways Gene Expression Profiles in Pediatric De Novo Acute Lymphoblastic and Myeloid Leukemia with FLT3 Mutations: Implications for Targeted Therapy.
International journal of molecular sciences - 4 Sept 2024
Zhao Lizhen, Chen Hongbo, Lan Fengli, Hao Jinjin, Zhang Wenzhi, Li Ying, Yin Yuhong, Huang Minchun, Wu Xiaoyan
Abstract excerpt
Activating FLT3 mutations plays a crucial role in leukemogenesis, but identifying the optimal candidates for FLT3 inhibitor therapy remains controversial. This study aims to explore the impacts of FLT3 mutations in pediatric acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) and...
Topics
- Humans
- fms-Like Tyrosine Kinase 3
- Mutation
- Child
- Male
- Female
- Leukemia, Myeloid, Acute
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Child, Preschool
- Prognosis
- Transcriptome
- Infant
- Adolescent
- Retrospective Studies