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Article

[FLT3 mutations in children with acute myeloid leukemia: a single center study].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 1 Nov 2011

Ruan Min, Wang Ya-Qin, Zhang Li, Liu Tian-Feng, Liu Fang, Liu Xiao-Ming, Zhang Jia-Yuan, Zou Yao, Chen Yu-Mei, Zhu Xiao-Fan

Abstract excerpt

OBJECTIVE: To study the clinical significance of FMS-like tyrosine kinase 3 (FLT3) mutations including internal tandem duplication (ITD) mutation and point mutation of tyrosine kinase domain (TKD) in children with acute myeloid leukemia (AML). METHODS: Bone marrow samples from 116 children with newly-diagnosed AML were obtained. Gene mutations of FLT3/ITD and FLT3/TKD were detected by RT-PCR. The relationship of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22099191

Genes

FLT3

Provenance

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FLT3 Mutations in Acute Myeloid Leukemia: Unraveling the Molecular Mechanisms and Implications for Targeted TherapiesSemantic proximity Read ↗

Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation.Semantic proximity Read ↗

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