Article

p300 KAT regulates SOX10 stability and function in human melanoma

2024-02-23

Abstract excerpt

SOX10 is a lineage-specific transcription factor critical for melanoma tumor growth, while SOX10 loss-of-function drives the emergence of therapy-resistant, invasive melanoma phenotypes. A major challenge has been developing therapeutic strategies targeting SOX10’s role in melanoma proliferation, while preventing a concomitant increase in tumor cell invasion. Here, we report that the lysine acetyltransferase (KAT)...

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Identifiers and source

Literature Corpus work: 74646f8a-7d3c-5d8f-8787-1c86447e5d85
DOI: 10.1101/2024.02.20.581224

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