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Article

Identification and functional analysis of SOX10 phosphorylation sites in melanoma

9 Jan 2018

Abstract excerpt

The transcription factor SOX10 plays an important role in vertebrate neural crest development, including the establishment and maintenance of the melanocyte lineage. SOX10 is also highly expressed in melanoma tumors, and SOX10 expression increases with tumor progression. The suppression of SOX10 in melanoma cells activates TGF-β signaling and can promote resistance to BRAF and MEK inhibitors. Since resistance to...

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PMID: 29315345
DOI: 10.1371/journal.pone.0190834

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