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Article

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells.

Epigenetics & chromatin - 9 Aug 2019

Fufa Temesgen D, Baxter Laura L, Wedel Julia C, Gildea Derek E, Loftus Stacie K, Pavan William J

Abstract excerpt

BACKGROUND: The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyance from the cell membrane to the nucleus, the transcriptional and epigenetic mechanisms that govern gene expression downstream of MAPK signaling are not fully elucidated. RESULTS: This study...

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Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31399133
DOI: 10.1186/s13072-019-0297-2
PMCID: PMC6688322

Genes

SOX10
MITF
BRAF

Variants

Provenance

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