Article

Cross-species analysis reveals unique and shared roles of Sox9 and Sox10 (SOXE family) transcription factors in melanoma

2022-12-06

Abstract excerpt

<h4>ABSTRACT</h4> SOX9 and SOX10 are two highly similar transcription factors with nearly 100% identity at their DNA binding domains. Both transcription factors play key but distinct roles in neural crest cell fate specification and melanoma formation. High expression of SOX9 and SOX10 appear to be mutually exclusive, with high SOX10 characteristic of proliferative melanoma and high SOX9 characteristic of metasta...

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Literature Corpus work: 603f48a2-b253-55d6-9243-540ddc3c9e81
DOI: 10.1101/2022.12.05.519210

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