Article

Super-Enhancers Orchestrate Transcriptional Dysregulation and Metabolic Reprogramming in Uveal Melanoma

2024-01-17

Abstract excerpt

<title>Abstract</title> <p>Uveal melanoma (UM) is the most common intraocular malignancy which frequently metastasizes. Somatic mutations and chromatin aberrations have been identified in the pathogenesis of this deadly disease. Despite rapid progress in uveal melanoma genetic landscape, the epigenetic architecture in UM pathogenesis has not been fully clarified. Here, we describe a super enhancer-medicated epige...

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Literature Corpus work: c879409e-adcd-537a-841f-8d665db1f17f
DOI: 10.21203/rs.3.rs-3719277/v1

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