Article
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.
Nature communications - 16 Mar 2022
Capparelli Claudia, Purwin Timothy J, Glasheen McKenna, Caksa Signe, Tiago Manoela, Wilski Nicole, Pomante Danielle, Rosenbaum Sheera, Nguyen Mai Q, Cai Weijia, Franco-Barraza Janusz, Zheng Richard, Kumar Gaurav, Chervoneva Inna, Shimada Ayako, Rebecca Vito W, Snook Adam E, Hookim Kim, Xu Xiaowei, Cukierman Edna, Herlyn Meenhard, Aplin Andrew E
Abstract excerpt
Cellular plasticity contributes to intra-tumoral heterogeneity and phenotype switching, which enable adaptation to metastatic microenvironments and resistance to therapies. Mechanisms underlying tumor cell plasticity remain poorly understood. SOX10, a neural crest lineage transcription factor, is heterogeneously expressed in melanomas. Loss of SOX10 reduces proliferation, leads to invasive properties, including...
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