Article

Specific <i>SOX10</i> enhancer elements modulate phenotype plasticity and drug resistance in melanoma

2024-12-17

Abstract excerpt

Recent studies indicate that the development of drug resistance and increased invasiveness in melanoma is largely driven by transcriptional plasticity rather than canonical coding mutations. Understanding the mechanisms behind cell identity shifts in oncogenic transformation and cancer progression is crucial for advancing our understanding of melanoma and other aggressive cancers. While distinct melanoma phenotypi...

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Literature Corpus work: 1d20c19f-1578-5d29-9eb1-e6d3bd33a09a
DOI: 10.1101/2024.12.12.628224

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