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Article

SOX5 is involved in balanced MITF regulation in human melanoma cells.

BMC medical genomics - 29 Feb 2016

Kordaß Theresa, Weber Claudia E M, Oswald Marcus, Ast Volker, Bernhardt Mathias, Novak Daniel, Utikal Jochen, Eichmüller Stefan B, König Rainer

Abstract excerpt

BACKGROUND: Melanoma is a cancer with rising incidence and new therapeutics are needed. For this, it is necessary to understand the molecular mechanisms of melanoma development and progression. Melanoma differs from other cancers by its ability to produce the pigment melanin via melanogenesis; this biosynthesis is essentially regulated by microphthalmia-associated transcription factor (MITF). MITF regulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26927636
DOI: 10.1186/s12920-016-0170-0
PMCID: PMC4772287

Genes

MITF
SOX5
SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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