Article

Phenotypic screening for small molecules that lower PrP in cultured cells

2026-04-09

Abstract excerpt

PrP lowering is a validated therapeutic hypothesis in prion disease. To identify small molecules that reduce PrP levels, we performed phenotypic screening in cultured cells. To prioritize PrP specificity in our primary screen, we generated mouse N2a cells stably expressing GFP and used high content imaging analysis to select compounds that lowered PrP without affecting GFP signal or cell viability. Screening a cur...

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Literature Corpus work: 74272edc-d089-5bae-ae32-ca5536ede557
DOI: 10.64898/2026.04.07.716919

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