Article

Therapeutic trial of anle138b in mouse models of genetic prion disease

2022-10-12

Abstract excerpt

Phenotypic screening has yielded small molecule inhibitors of prion replication that are effective in vivo against certain prion strains but not others. Here we sought to test the small molecule anle138b in multiple mouse models of prion disease. In mice inoculated with the RML strain of prions, anle138b doubled survival and durably suppressed astrogliosis measured by live animal bioluminescence imaging. In knock-...

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Literature Corpus work: 73250ffb-9b3b-5407-8aa4-e3ebcfdda9a9
DOI: 10.1101/2022.10.11.511739

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