Article

A high-content imaging workflow to screen for molecules that reduce cellular uptake of α-synuclein preformed fibrils

2025-12-24

Abstract excerpt

A classical pathological hallmark of many neurodegenerative diseases is the formation of protein-rich aggregates and inclusions. In Parkinson’s disease (PD), α-synuclein (α-syn) constitutes a major protein component of pathological inclusions, termed Lewy bodies. These α-syn aggregates are hypothesized to spread throughout the nervous system by cell-to-cell transmission acting as templates to amplify aggregate for...

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Literature Corpus work: ff531a03-434b-5038-9949-68a9c7002031
DOI: 10.64898/2025.12.22.695981

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