Article

PrP turnover in vivo and the time to effect of prion disease therapeutics

2024-11-14

Abstract excerpt

PrP lowering is effective against prion disease in animal models and is being tested clinically. Therapies in the current pipeline lower PrP production, leaving pre-existing PrP to be cleared according to its own half-life. We hypothesized that PrP’s half-life may be a rate-limiting factor for the time to effect of PrP-lowering drugs, and one reason why late treatment of prion-infected mice is not as effective as...

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Identifiers and source

Literature Corpus work: 0eca6b89-69e2-5667-8720-492d2fc06821
DOI: 10.1101/2024.11.12.623215

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