Article

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains, and endpoints

2020-03-29

Abstract excerpt

Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-mediated PrP suppression extends survival and delays disease onset in intracerebrally prion-infected mice in both prophylactic and delayed dosing paradigms. Here, we examine the efficacy of this therapeutic approach across diverse paradi...

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Identifiers and source

Literature Corpus work: 8ba72199-27a7-5f7a-9af3-041ab5b2f604
DOI: 10.1101/2020.03.27.011940

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