Article

Genome-wide arrayed CRISPR activation screen for prion protein modulators

2026-03-02

Abstract excerpt

The cellular prion protein (PrP C ) is an essential substrate for prion propagation, and its abundance strongly influences susceptibility to prion disease. To systematically identify genetic regulators of PrP C abundance, we performed an arrayed genome-wide CRISPR activation (CRISPRa) screen targeting 19,839 human protein-coding genes in human glioblastoma cells. Using a quantitative time-resolved fluorescence r...

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Literature Corpus work: 60d1277c-08c4-54a6-b722-987acd5b6468
DOI: 10.64898/2026.03.01.707423

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