Article

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

2026-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Prion propagation, in which the cellular prion protein (PrP C ) is conformationally converted into an infectious structure (PrP Sc ), is now well understood. However, the molecular mechanism responsible for the neurotoxicity of prions remains unclear. Synaptic loss is one of the earliest events in both in vivo and in vitro models of prion disease. We previously developed a neuronal cell cult...

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Literature Corpus work: 7a07b542-96db-5e68-b4a9-16cf8a0a75ff
DOI: 10.64898/2026.01.28.702331

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