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Article

Discovery of 2-Aminothiazoles as Potent Antiprion Compounds

24 Dec 2009

Abstract excerpt

Prion diseases are fatal, untreatable neurodegenerative diseases caused by the accumulation of the misfolded, infectious isoform of the prion protein (PrP), termed PrP(Sc). In an effort to identify novel inhibitors of prion formation, we utilized a high-throughput enzyme-linked immunosorbent assay (ELISA) to evaluate PrP(Sc) reduction in prion-infected neuroblastoma cell lines (ScN2a). We screened a library of...

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PMID: 20032192
DOI: 10.1128/jvi.02145-09

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