Article

A Stacking Framework for Polygenic Risk Prediction in Admixed Individuals

2024-02-03

Abstract excerpt

1.1 Polygenic risk scores (PRS) are summaries of an individual’s personalized genetic risk for a trait or disease. However, PRS often perform poorly for phenotype prediction when the ancestry of the target population does not match the population in which GWAS effect sizes were estimated. For many populations this can be addressed by performing GWAS in the target population. However, admixed individuals (whose gen...

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Literature Corpus work: 7406c595-2b8f-50bf-bceb-5c9b2733c155
DOI: 10.1101/2024.01.31.24302103

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