Article
Personalized polygenic risk prediction and assessment with a Mixture-of-Experts framework
2025-09-17
Abstract excerpt
With the increasing availability of high quality genomic data from diverse cohorts, polygenic scores (PRS) have become a mainstay of genetic analyses of complex traits and diseases. Despite their proliferation in numerous research domains, a major obstacle to wider adoption in clinical settings has been the well-established heterogeneity in prediction accuracy across a variety of demographic variables, such as age...
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Identifiers and source
- Literature Corpus work
- 25f52d0b-2228-584c-898b-e4ac5286228e
- DOI
- 10.1101/2025.09.15.676165