Article

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

2020-11-27

Abstract excerpt

The accuracy of polygenic risk scores (PRSs) to predict complex diseases increases with the training sample size. PRSs are generally derived based on summary statistics from large meta-analyses of multiple genome-wide association studies (GWAS). However, it is now common for researchers to have access to large individual-level data as well, such as the UK biobank data. To the best of our knowledge, it has not yet...

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Literature Corpus work: c93938e3-b815-51f1-ba4e-d2c204acd298
DOI: 10.1101/2020.11.27.401141

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