Article
Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction.
American journal of human genetics - 3 Jun 2021
Albiñana Clara, Grove Jakob, McGrath John J, Agerbo Esben, Wray Naomi R, Bulik Cynthia M, Nordentoft Merete, Hougaard David M, Werge Thomas, Børglum Anders D, Mortensen Preben Bo, Privé Florian, Vilhjálmsson Bjarni J
Abstract excerpt
The accuracy of polygenic risk scores (PRSs) to predict complex diseases increases with the training sample size. PRSs are generally derived based on summary statistics from large meta-analyses of multiple genome-wide association studies (GWASs). However, it is now common for researchers to have access to large individual-level data as well, such as the UK Biobank data. To the best of our knowledge, it has not...
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