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Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines

16 Feb 2024

Abstract excerpt

In normal intestines, a fetal/regenerative/revival cell state can be induced upon inflammation. This plasticity in cell fate is also one of the current topics in human colorectal cancer (CRC). To dissect the underlying mechanisms, we generated human CRC organoids with naturally selected genetic mutation profiles and exposed them to two different conditions by modulating the extracellular matrix (ECM). Among...

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PMID: 38439969
DOI: 10.1016/j.isci.2024.109247

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