Article

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

2021-01-11

Abstract excerpt

<h4>SUMMARY</h4> Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent SARS-CoV-2-neutralizing antibodies yet identified. To provide insight into whether these genetic similarities inform common modes of recognition, we determined structures of the SARS-CoV-2 spike in complex with three VH1-2-derived antibodies: 2-15, 2-43, and H4. All three utilized VH1-2-encoded motifs...

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Literature Corpus work: 6e69031c-e013-5464-8f87-392274ad1dff
DOI: 10.1101/2021.01.11.426218

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