Article

HSV-1 Infection Alters <i>MAPT</i> Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

2024-10-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer’s Disease (AD) in neurons. One key marker of AD is the hyperphosphorylation of Tau, accompanied by altered levels of Tau isoforms. However, an imbalance in these Tau splice variants, specifically resulting from altered 3R to 4R MAPT splicing of exon 10, has yet to be directly associated with HSV...

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Literature Corpus work: 73a91fde-6970-5103-bf3e-4cc64edc07a9
DOI: 10.1101/2024.10.16.618683

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