Article

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1

2021-03-07

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) infection of the nervous system may lead to brain damage, including neurodegeneration. However, lack of suitable experimental models hinders understanding molecular mechanisms and cell-type-specific responses triggered by HSV-1. Here, we infected human brain organoids with HSV-1. Known features of HSV-1 infection such as alteration of neuronal electrophysiology and induction of...

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Literature Corpus work: c8fd334d-c0eb-51ef-81b5-e8833247f32e
DOI: 10.1101/2021.03.05.434122

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