Article

Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytoplasmic side

2021-06-03

Abstract excerpt

<title>Abstract</title> <p>Na<sup>+</sup>/K<sup>+</sup>-ATPase (NKA) is a membrane-bound ion pump that generates electrochemical gradient of sodium ion and potassium ion across the plasma membrane via hydrolyzing ATP. During each so-called Post-Albers cycle, NKA exchanges three cytoplasmic sodium ions for two extracellular potassium ions through alternating E1 and E2 states. Hitherto, there are several steps rema...

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Literature Corpus work: 739d26f9-35ac-5c71-a3c0-c06918644ed6
DOI: 10.21203/rs.3.rs-557882/v1

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