Article
Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.
Science (New York, N.Y.) - 4 Oct 2013
Nyblom Maria, Poulsen Hanne, Gourdon Pontus, Reinhard Linda, Andersson Magnus, Lindahl Erik, Fedosova Natalya, Nissen Poul
Abstract excerpt
The Na(+), K(+)-adenosine triphosphatase (ATPase) maintains the electrochemical gradients of Na(+) and K(+) across the plasma membrane--a prerequisite for electrical excitability and secondary transport. Hitherto, structural information has been limited to K(+)-bound or ouabain-blocked forms. We present the crystal structure of a Na(+)-bound Na(+), K(+)-ATPase as determined at 4.3 Å resolution. Compared with the...
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