Article
Structural and functional interaction sites between Na,K-ATPase and FXYD proteins.
The Journal of biological chemistry - 10 Sept 2004
Li Ciming, Grosdidier Aurelien, Crambert Gilles, Horisberger Jean-Daniel, Michielin Olivier, Geering Käthi
Abstract excerpt
Several members of the FXYD protein family are tissue-specific regulators of Na,K-ATPase that produce distinct effects on its apparent K(+) and Na(+) affinity. Little is known about the interaction sites between the Na,K-ATPase alpha subunit and FXYD proteins that mediate the efficient association and/or the functional effects of FXYD proteins. In this study, we have analyzed the role of the transmembrane segment...
Topics
- Alanine
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Membrane
- DNA Mutational Analysis
- Electrophysiology
- Glutamine
- Leucine
- Membrane Potentials
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed