Article

Active Conformations of Neuronal Na <sup>+</sup> ,K <sup>+</sup> -ATPase isoforms and a Disease-Causing Mutant

2025-07-27

Abstract excerpt

Na + ,K + -ATPases establish and maintain the vital electrochemical gradients for Na + and K + across animal cell membranes. The protein is a ternary complex composed of α, β and FXYD subunits, of which isoforms that fine-tune transport properties are expressed in a tissue-specific fashion. Here we report cryo-EM structures under active ATPase turn-over conditions of the ubiquitously expressed human α1β1FXYD1...

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Literature Corpus work: 0fdc59c2-0a49-5bc5-adc1-a5c20dc1a568
DOI: 10.1101/2025.07.27.666930

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