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Article

Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations.

Nature communications - 29 Sept 2021

Abe Kazuhiro, Yamamoto Kenta, Irie Katsumasa, Nishizawa Tomohiro, Oshima Atsunori

Abstract excerpt

The gastric H+,K+-ATPase mediates electroneutral exchange of 1H+/1K+ per ATP hydrolysed across the membrane. Previous structural analysis of the K+-occluded E2-P transition state of H+,K+-ATPase showed a single bound K+ at cation-binding site II, in marked contrast to the two K+ ions occluded at sites I and II of the closely-related Na+,K+-ATPase which mediates electrogenic 3Na+/2K+ translocation across the...

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Identifiers

PMID: 34588453
DOI: 10.1038/s41467-021-26024-1
PMCID: PMC8481561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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