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Article

Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells

2022-08-06

Abstract excerpt

<h4>Background</h4> Exposure to elevated interleukin (IL)-6 levels in utero is consistently associated with increased risk for psychiatric disorders with a putative neurodevelopmental origin, such as schizophrenia (SZ) and autism spectrum condition (ASC). Although rodent models provide causal evidence for this association, we lack a detailed understanding of the cellular and molecular mechanisms in human model s...

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Literature Corpus work
7392bce3-1461-5cb5-a143-3d489d8d1dd0
DOI
10.1101/2022.08.05.502958
Open publication

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Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cellsDOI 10.1101/2022.08.05.502958
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