Article

Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence

2022-05-23

Abstract excerpt

<h4>Summary</h4> Early life stress, prenatal exposure to glucocorticoids (GCs), confers a higher risk of psychiatric and neurodevelopmental disorders in children. Increasingly, the importance of microglia in these disorders has been recognised. Studies on GCs exposure during microglial development have been limited, and there are few, if any, human studies. We established an in vitro model of ELS by continuous p...

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Literature Corpus work: 452180be-53e5-575a-9d89-5f7e202e3bb4
DOI: 10.1101/2022.05.23.493044

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